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The most effective experiment for determining the distribution of touch receptors in the skin is having a blindfolded person identify bristle touches. This method is designed to specifically test the sensory perception related to touch, as it directly engages the participant's tactile discrimination skills. By using bristles to provide localized stimuli on different areas of the skin, it allows researchers to observe variations in sensitivity across various regions. This approach can reveal areas of higher receptor density, where the participant is able to identify touches more easily, compared to less sensitive areas.

In contrast, measuring pressure with a scale primarily assesses general pressure sensitivity rather than the distribution of receptors. Testing with varying weights could also provide insights into pressure sensitivity but does not specifically target the ability to identify touch in different skin regions. Mapping temperature sensitivity focuses on a different type of sensory receptor entirely, which is not relevant when examining the distribution of touch receptors.